Genetic polymorphisms and heart failure
نویسندگان
چکیده
منابع مشابه
Genetic polymorphisms associated with heart failure: A literature review
OBJECTIVE To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. METHODS Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015. RESULTS Eighty-two articles covering 29 genes and 39 polymorphisms were identified. C...
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Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and economic burden of heart failure (HF) remain unacceptably high. There is increasing evidence that the risk and course of HF depend on genetic predisposition; however, the genetic contribution to HF is heterogeneous and complex. At one end of the spectrum are the familial monogenic HF syndromes in which ...
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The selfish gene has little interest in the welfare of its host after reproduction. This teleological concept, albeit simplistic in the present context, may partly explain why the neuroendocrine compensatory mechanisms that have evolved for congestive cardiac failure, a condition affecting mostly older patients, are fundamentally flawed. One of these misguided compensatory responses is chronic ...
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Background: Clopidogrel is a standout amongst the most ordinarily recommended medications to avoid ischemic occasions taking after coronary disorder or stant position. However, impaired responses the therapy as well as resistance to the therapy have also been reported. Genetic variants play an important role in clopidogrel biotransformation of its active metabolite that may subsequently influen...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 2004
ISSN: 1098-3600,1530-0366
DOI: 10.1097/01.gim.0000144061.70494.95